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I was very surprised to see your post today on my first visit to this message board. I have a 2nd great grandmother named Sophia Picot (Picott, Picotte) who is sometimes referred to as Picot Laysell. I did not know that these 2 names actually can belong together until I read your message. So you can see that I am not an expert on this name, but find your post giving me a clue. ( I believe I have one record that says her father was a Picot Layzelle) I do not know the origin of the name, but can tell you that my Sophia is presumed to be French Canadian having been born in Canada and married Levi Bashaw (Bachand, etc) who was born on St Hyancinthe, Quebec. They settled in Brandon , Vermont. I believe that one of their daughters married a Layzelle also.
Can you tell me more about the name Picot Lasell?